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Postdoc: Drug-induced Nephrogenic diabetes insipidus
Organization: Radboud University Nijmegen Medical Centre
Location: Nijmegen, Netherlands
Field: Biological sciences
Requirements:
PhD or equivalent in Biological Sciences;
• Experience with molecular & cell biology or relevant animal research
• Independent and well-structured working style
• Strong motivation to succeed in scientific research
• Well-developed social skills directed to work in a team
• Excellent interpersonal and communicative skills
• Interest in transport physiology and clinically-oriented research
• Interest to work abroad
English: excellent
Abstract:
Daily we produce 180 liters of pro-urine in the kidney of which 1.5 liter is voided. The remaining 178 liters is reabsorbed through water-selective channels, so-called Aquaporins...
Description:
Daily we produce 180 liters of pro-urine in the kidney of which 1.5 liter is voided. The remaining 178 liters is reabsorbed through water-selective channels, so-called Aquaporins (AQPs; see Nobel laureate Chemistry 2003). Concentration of urine occurs through insertion of AQP2 into the apical membrane of renal principal cells, which is regulated by the antidiuretic hormone vasopressin (AVP). Several drugs lead to Nephrogenic Diabetes Insipidus (NDI), a disorder in which AQP2 translocation and production is disturbed leading to excessive water loss. Using molecular/cell/system biology techniques on recently-established excellent cell and animal models, our goal in this international project is to unravel the mechanism underlying drug-induced NDI.
Deadline: 31-03-2011
Contacts:
Link: http://www.physiology-nijmegen.nl
Email: p.deen@fysiol.umcn.nl
Phone number: phone +31-243617347
Phone number: mobile +31-613442286
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