Eurizon.eu

Organization: Newcastle University

Location: Newcastle, UK

Field: Cancer Research

Requirements:

The successful candidate will have a first degree in chemistry or a related subject (e.g. pharmacy). They will demonstrate strong theoretical and practical skills in organic chemistry. Previous experience of medicinal or biological chemistry is an advantage but not essential.

Abstract:

Deregulation of extracellular related kinase 5 (ERK5), also known as big mitogen activated protein kinase 1 (BMK1), signalling is associated with a number of cancers, such as prostate cancer, breast cancer, and hepatocellular carcinoma

Description:

Deregulation of extracellular related kinase 5 (ERK5), also known as big mitogen activated protein kinase 1 (BMK1), signalling is associated with a number of cancers, such as prostate cancer, breast cancer, and hepatocellular carcinoma. We have identified small-molecule inhibitors of ERK5 with good potential for development into drug candidates. The aims of the project are to optimise and expand the current lead series to generate compounds with potency, kinase selectivity, drug-like properties, and cellular and in vivo activity. The ultimate aim is to develop ERK5 inhibitors for clinical evaluation as a cancer therapy.
The student will design and synthesise small-libraries of compounds for biological evaluation. guided by modelling and SARs. Key compounds will be profiled for kinase selectivity, and in vitro and in vivo antitumour activity.
The student will work in a strong multidisciplinary team of chemists and biologists, with primary training  in medicinal chemistry, organic synthetic methods (microwave and parallel) and analytical techniques (LC-MS, NMR, and FTIR), and secondary training in cancer pharmacology and oncology.
 
How to Apply
You must apply through the University's online postgraduate application form inserting the reference number CR048 and selecting 'Master of Research/Doctor of Philosophy (Medical Sciences) - Cancer Research' as the programme of study.  Only mandatory fields need to be completed (no personal statement required) and a covering letter, CV and (if English is not your first language) a copy of your English language qualifications must be attached. The covering letter must state the title of the studentship, quote the reference number CR048 and state how your interests and experience relate to the project.
You should also send your covering letter and CV to Ian Hardcastle, Northern Institute for Cancer Research, Bedson Building Newcastle University, Newcastle upon Tyne, NE1 4RW, or by e-mail to I.R.Hardcastle@ncl.ac.uk

Deadline: 04-03-2011

Contacts:

Email: I.R.Hardcastle@ncl.ac.uk

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