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Postdoc at the Department of Genome Sciences
Organization: University of Washington
Location: Washington, USA
Field: Genome Sciences
Requirements:
We are currently recruiting postdoctoral candidates with strong backgrounds in molecular and cell biology, mass spectrometry and proteomics and/or quantitative sciences. Strong candidates must enjoy working in a collaborative environment and be enthusiastic about developing and using high-throughput techniques and systems-level analyses to tackle questions in biological signal transduction.
Abstract:
The Wolf-Yadlin lab in the Department of Genome Sciences at the University of Washington and member of the University of Washington Proteomics Resource currently has exceptional opportunities for postdoctoral research on receptor tyrosine kinase (RTK)-mediated signaling networks.
Description:
The Wolf-Yadlin lab in the Department of Genome Sciences at the University of Washington and member of the University of Washington Proteomics Resource currently has exceptional opportunities for postdoctoral research on receptor tyrosine kinase (RTK)-mediated signaling networks. We are interested in understanding the mechanism of RTK-mediated signaling at a systems level. Our current efforts focus on TRKB an RTK whose deregulation has been implicated in several types of cancer, most notably neuroblastoma, as well as in various diseases of the nervous system such as schizophrenia and Alzheimers disease. Our approach involves the development and application of novel mass spectrometry- and microarray-based methodologies to quantitatively measure dynamic changes of large numbers of signaling proteins, to elucidate the connectivity of RTK-mediated signaling networks and their relationship to cellular phenotype and gene expression.
Specific areas of research include
- Developing new tools, in particular mass spectrometry based techniques to measure and quantify post-translational modification of proteins in complex biological contexts.
- The study of complex biological systems and diseases such as cancer, diabetes, Alzheimers disease and other neurodegenerative diseases.
- Developing computational models to understand the topology and dynamics of cellular signaling networks, their relationship with cellular phenotype and disease progression.
Multiple postdoctoral positions are currently available. To apply, email a cover letter describing your research interests, a detailed CV and three letters of reference to ayadlin@uw.edu
Sample references:
Sevecka M, Wolf-Yadlin A, MacBeath G. Lysate microarrays enable high-throughput, quantitative investigations of cellular signaling. Mol Cell Proteomics. In press mcp.M110.005363. Epub 2011 Feb 4, doi:10.1074/mcp.M110.005363
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5860-5. Epub 2007 Mar 26.
Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova V, Lauffenburger DA, White FM. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol. 2006;2:54. Epub 2006 Oct 3.
Deadline: 30-03-2011
Contacts:
Email: ayadlin@uw.edu
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