Eurizon.eu

Organization: Academic Medical Center

Location: Amsterdam, Netherlands

Field: Medical sciences

Requirements:

We ask for an enthusiastic molecular biologist with greater than average knowledge of molecular biology and neurobiology, including affinity for bioinformatics and neuro-oncology. Participation in the education of Medical and Medical Biology students is part of the job.

Abstract:

Glioneuronal tumors (GNT’s) are the most frequent brain tumors in children with refractory epilepsy. These tumors consist of a mixture of dysplastic neurons and neoplastic glial cells...

Description:

Glioneuronal tumors (GNT’s) are the most frequent brain tumors in children with refractory epilepsy. These tumors consist of a mixture of dysplastic neurons and neoplastic glial cells. Little information is available on the specific genetic changes, malignant transformations and relapse in the different subtypes of GNT’s. The chances for relapse and/or progression are unpredictable. A better insight is required in the biologic mechanisms related to such unfortunate behavior of the tumor. The identification of a biologic risk profile can contribute to a diagnostic classification for risk stratification, which can be helpful in decisions on additional treatment in subgroups of patients. The aim of the study is to identify chromosomal changes in an international large series of GNT’s by genomic wide microarray based comparative genomic hybridization (aCGH), PCR and genomic sequencing. During the project these chromosomal changes will be investigated for their potential clinical relevance as related to prognosis, pathogenesis en epileptogenesis. By investigating these biologic characteristics in relation to the clinical data, we can improve the diagnostics and therapy for GNT’s in children, as guided by the clinical biological risk profile of the tumor. This is a 4 year research project and the PhD student will write a thesis on this subject.
 
We offer a dynamic research environment with the opportunity to increase your knowledge in neurobiology, neuropathology and neurogenetics. The laboratory for Neuropathology is located within the department of general Pathology and focuses on brains, brain tumors, muscle and nerve diagnostics. A tight connection in research is present between the departments of neuropathology, pediatric oncology and genome analysis, which facilitates to increase knowledge on neurologic and genetic research questions. Moreover you will participate in an interesting project with national and international research cooperation. A 4 year PhD-contract with excellent terms, including a 36-hour work week, pension, holiday pay (8.0%) and a 13th month (8.3%). Salary is based on experience, ranging from 2.086,00 in the first year up to 2.673,00 in the fourth year.

Deadline: 29-04-2011

Contacts:

Link: http://www.amc.nl/

Email: wens@amc.nl

If you apply for this position please say you saw it on eurizons.eu