Eurizon.eu

Organization: Structural Genomics Consortium, University of Toronto

Location: Toronto, CANADA

Field: Chemical Biology

Abstract:

The SGC has recently launched a public-private partnership to generate small molecule “chemical probes” for use in research on epigenetic signaling.

Description:

The SGC has recently launched a public-private partnership to generate small molecule “chemical probes” for use in research on epigenetic signaling. Using the SGC’s strength in making active recombinant human proteins, we will develop inhibitors of three important protein families involved in epigenetic signaling: the Histone Methyltransferases, Histone Acetyltransferases and members of the “Royal Family” of chromatin-interacting domains. We aim to develop 12 chemical probes with pre-defined potencies, selectivities and cellular activities for use in biological research. The chemical probes will be made available without restrictions on use and the associated data will be placed into the public domain via publications and deposition into public databases. We are actively working with industrial and academic medicinal chemists and with local and international investigators who will use our probes to accelerate research on the role of epigenetic signaling in human biology and diseases, such as cancer, inflammation, mental illness and stem cell biology.
The Toronto site of the SGC seeks adventurous, motivated scientists to work in collaboration with protein biochemists, structural biologists, and medicinal chemists to develop in-vitro/vivo assays to characterize chemical probes.
Postdoctoral Fellow: 0-2 years post-PhD, with experience in enzymology and/or cell-based assays.
Interested Candidates please send CV and statement of interest to Peter Brown peterj.brown@utoronto.ca

Deadline: 01-05-2011

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