Eurizon.eu

Organization: University of Groningen

Location: Groningen, Netherlands

Field: Medical sciences

Requirements:

- PhD degree in (molecular) genetics or neuroscience. Candidates with experience in bioinformatics and next generation sequencing will have a strong advantage. - Excellent team player in multi-disciplinary environment. - Independent, enthusiastic, accurate, and highly motivated researcher. - Strong interest in human genetics, neurogenetics and neuroscience. The UMCG has a preventive Hepatitis B policy. This means that you must have built up sufficient protection against Hepatitis B before you can be appointed

Abstract:

Spinocerebellar ataxia (SCA) is a progressive neurodegenerative disorder and is genetically very heterogeneous.

Description:

Spinocerebellar ataxia (SCA) is a progressive neurodegenerative disorder and is genetically very heterogeneous. Despite the fact that many disease genes are known, some 30% of the ataxia patients can still not be genetically diagnosed. Here we propose to use whole exome sequencing. a next generation sequencing technology, to identify novel SCA genes in families in whom no genetic diagnosis could be made so far. We have recently developed an ataxia gene-gene interaction network. This will allow us to immediately select for those variations in genes residing in this network and identified by exome sequencing. We can thus use them to predict which genes participate in the common ataxia pathways and to highlight some of the emerging pathways leading to cerebellar neurodegeneration. In addition, potentially disease-causing variations will be functionally screened in cell- and Drosophila models. The postdoc will be responsible for the daily coordination of the project. In collaboration with the genome facility, the postdoc will prepare the DNA libraries, analyze the exome sequence data, and perform the functional assays in order to identify disease-causing variations underlying SCA.

Deadline: 08-03-2011

Contacts:

Link: http://www.werken.umcg.nl/

Email: vacaturemeldpunt@p-o.umcg.nl

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